Nicotinamide, energy, brain clarity, feel better, NAD

What is NAD+?

NAD+ stands for Nicotinamide Adenine  Dinucleotide, an essential molecule found in every cell of your body.  It is a coenzyme of Vitamin B3 (niacin), which means it’s a small "helper" molecule that helps activate an enzyme. Enzymes are responsible for over 5,000 different biochemical reactions throughout the body and NAD+ participates in more reactions than any other vitamin-derived molecule. NAD+ is basically the building block of a healthy body that the brain, our internal organs and neurological systems need to function at optimal efficiency.  One of the many uses of NAD+ treatments is to have more energy.

What's the big deal?

NAD+ levels decline as we age.  Levels also decline with any chronic illness, exposure, pain, stress, etc.  Basically, anything that your body has to "deal" with uses NAD+.  If we are using up our NAD+ faster than we can replenish it, this can have a significant impact on our lives.  Decreased NAD+ can lead to faster aging, decreased mental clarity, decreased physical performance.

NAD+ is directly involved in our body's ability to make ENERGY.

Supplementing with IV NAD+ has been shown to help with stress, chronic fatigue, chronic pain, addiction, depression, anxiety, and many other chronic ailments.  

NAD+ infusions can have the following benefits:  better sleep, increased clarity of mind, better problem-solving ability, improved focus and concentration, increased energy, improvement in mood, decreased anxiety levels, decreased levels of pain, and reduced cravings.




How does NAD+ work?

increased energy woman and man, playing with kids, happy woman

A little bit of history...

NAD+ is part of cellular respiration - meaning for cells to function properly, there must be NAD+ present.  The importance of NAD+ became apparent after a study of pellagra - a disease characterized by a darkly pigmented rash, dermatitis, diarrhea, and dementia...ultimately resulting in death.  This was in 1958.  Pellagra was common in rural areas of Europe and became an epidemic in the southern areas of the United States - this was  a century ago.  

It was discovered that lack of vitamin B3, niacin, was the underlying cause of pellagra.  Niacin is a precursor for NAD+.  

Why is NAD+ important?

NAD+ plays a key role in hydrogen transfer in biochemical reactions, namely transferring a hydrogen ion into the process that is responsible for making our body's ENERGY.   However, we now know NAD+ also has other roles, such as helping other enzymes do their jobs.  

But...what does it DO??

  • NAD+ is used as a cofactor in glucose and fat breakdown, but when it is "carrying" a hydrogen ion, it becomes NADH - which is used to help our bodies make energy.  
  • NAD+ is used by "sirtuins", which are enzymes that are responsible for cellular adaptations that improve metabolic efficiency.  Loss of function of SIRT1, SIRT3, and SIRT7 as been linked to higher susceptibility to metabolic and age-related disease or reduced maximal lifespan.  When SIRT1 is increasingly active, it can protect against age-related complications including insulin resistance, obesity, and fatty liver.  SIRT1 activation is also important for our circadian rhythm (sleep cycle).  Basically, the more sirtuin activity we have - the better our health and the better we feel!  These enzymes are NAD+ dependent!  
  • NAD+ is necessary for DNA repair, which is going on all the time inside our bodies.  
  • Many clinics are now using NAD+ for its anti-aging effects.

What conditions may be improved with NAD+ therapy?

  • Anxiety
  • Stress
  • Substance abuse
  • Depression
  • PTSD
  • Insomnia
  • Chronic Fatigue
  • Chronic Pain
  • Alcoholism
  • Neurodegenerative disorders
  • Addiction

What are patients saying?

After treatments, patients generally report:

  • Increased energy
  • Improved mood
  • Decreased pain
  • Increased focus/concentration
  • Reduction in cravings
  • Increased mental clarity
  • Improved memory

NAD+ Pricing


Is a consultation required?

Yes, an in-office consultation is required.  The fee for the consultation is $100.  This fee is waived if a 30-day NAD+ protocol is completed.  

What are the side effects?

NAD+ has very little side effects.  Some patients experience a faster heart rate or lower blood pressure, but this is monitored closely.  Sometimes, the infusions can cause a pressure sensation in the chest that goes away if the infusion rate is turned down.  While this isn't dangerous, it can be alarming for some.  The sensation passes quickly once the drip rate is reduced.  

How long will the infusions take?

Patients should plan on each infusion lasting between 4-6 hours. 

Do I need a driver?

If just receiving NAD+, no - you do not need a driver.  If NAD+ is being combined with ketamine, you will need a driver as usual.  

Can I eat before the NAD+ infusions?

We prefer you not eat before you first NAD+ infusion.  This is simply to see how you do.  Once the infusion is going and things are fine, you are welcome to eat.  Many people bring food and snacks since you may be in the clinic for several hours.  

Why is NAD+ so expensive?

NAD+ treatments are costly - there's no question about that.  Pricing is based on the amount of time spent in the office and the cost of the NAD+.  Keep in mind, most treatments are a full month's protocol.  The chronic pain protocol is slightly higher than the mental health protocol simply because more NAD+ is used.  

What types of payments do you take?

Credit card


Care Credit

Will I ever have to come back for more NAD+?

Possibly, but the goal is to restore your NAD+ levels and get you feeling like your old self for many months.  


NAD+ qualifies as a supplement under FDA guidelines. These statements have not been evaluated by the Food and Drug Administration. Intravenous NAD+ therapy is not intended to diagnose, treat, cure, or prevent any disease.  There is no guarantee of response. 

Want more info about NAD+ infusions?

Drop us a line!

Iowa Ketamine Services, PLC